ODCs

Click node...

3 OMIM references -
3 associated genes
12 signs/symptoms

PROTEIN INTERACTIONS: 3
COMMON SIGNS: 3

1 OMIM reference -
1 associated gene
9 signs/symptoms

Multiple epiphyseal dysplasia due to collagen 9 anomaly

Legg-CalvÃ©-Perthes disease


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	COL9A1 COL9A3 COL9A2	(0.75) (0.62) (0.52)	COL2A1 COL2A1 COL2A1

Citations in the biomedical literature:

Multiple epiphyseal dysplasia due to collagen 9 anomaly		Legg-CalvÃ©-Perthes disease
	Synonym(s): (no synonyms)		Synonym(s): - Aseptic necrosis of the capital femoral epiphysis - Osteochondritis of the capital femoral epiphysis - Osteochondrosis of the capital femoral epiphysis - Perthes disease

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -

	Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant

	External references: 3 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Articular / joint pain / arthralgia - Joint / articular deformation - Short stature / dwarfism / nanism

Multiple epiphyseal dysplasia due to collagen 9 anomaly		Legg-CalvÃ©-Perthes disease
	Very frequent - Autosomal dominant inheritance - Epiphyseal anomaly - Osteoarthritis Frequent - Abnormal gait - Hip dislocation / dysplasia / coxa valga / coxa vara / coxa plana - Restricted joint mobility / joint stiffness / ankylosis - Short limbs / micromelia / brachymelia Occasional - Genu valgum - Genu varum		Very frequent - Abnormal dentition / dental position / implantation / unerupted / dental ankylosis - Cartilage destruction / chondrolysis - Delayed bone age - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Osteonecrosis / bone infarction - Polygenic / multifactorial inheritance